Angiotensin receptor-neprilysin inhibitor (ARNI) — heart failure medication
Generic name: sacubitril/valsartan
US Retail Price
$600–$750/month
With copay card: As low as $10/month (commercially insured)
Manufacturer
Novartis
Used For
Heart failure with reduced ejection fraction (HFrEF), also studied in HFpEF
Entresto does not yet have a US generic equivalent. The sacubitril/valsartan combination patent is expected to expire around 2025–2026. International pharmacies currently offer the most significant savings for Medicare patients.
Novartis offers a copay card that can reduce Entresto to as low as $10/month for commercially insured patients. Apply online and present at any US pharmacy. Not valid for Medicare/Medicaid.
Apply for Entresto Copay CardEntresto is available from verified international pharmacies for $60–$150/month — 80–90% less than US retail. This is often the best option for Medicare patients who cannot use copay cards.
Compare International PricesNovartis offers a Patient Assistance Program for patients who meet income requirements. Medicare and Medicaid patients who cannot afford Entresto should apply through NeedyMeds or RxAssist.
Search Entresto PAP on NeedyMedsGoodRx coupons can reduce Entresto cost at US pharmacies, though savings are more modest than for generics. Worth checking for the lowest local price.
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